Early menopause and premature ovarian insufficiency: problems and perspectives
نویسندگان
چکیده
منابع مشابه
I-41: Genetic Causes of Premature Ovarian Failure (POF) and early Menopause
Premature ovarian failure (POF) is a heterogeneous disorder, defined as menopause under age 40 years. The prevalence is 1%; POF before age 30 years is much less common. Chromosomal causes have long been recognized - visible deletions of the X chromosome, 45,X/46,XX mosaicism, and autosomal rearrangements (balanced translocations). Toxins or iatrogenic causes (e.g., chemotherapeutic agents) are ...
متن کاملO-31: AMH and AMHR2 Genetic Variants in Chinese Women with Primary Ovarian Insufficiency and Normal Age at Natural Menopause
Background To investigate the role of the anti-Müllerian hormone (AMH) signalling pathway in the pathophysiology of idiopathic primary ovarian insufficiency (POI) and age at natural menopause (ANM) using a genetic approach MaterialsAndMethods DNA sequencing was used to detect the genotype distribution and allele frequency of the genes AMH and AMH receptor II (AMHR2) in 120 cases of idiopathic P...
متن کاملRole of microRNAs in premature ovarian insufficiency
Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea lasting for a minimum of 4 months. The typical characteristics comprised of declined estrogen and raised serum concentrations of follicle-stimulating hormone (FSH) in women <40-year-old, primarily originating from iatrogenic factors, karyotypic abnormalities, and genetic factors. However, the etiology of POI remains unkno...
متن کاملEstrogen receptor-1 genetic polymorphisms for the risk of premature ovarian failure and early menopause.
BACKGROUND The aim of this study was to investigate the role of the estrogen receptor 1 (ESR1) genetic polymorphisms for early menopause that was classified as premature ovarian failure (POF) and early menopause (EM) and to examine whether the associations of ESR1 genetic variants are different for POF and EM. METHODS We selected 100 POF cases and matched 100 EM cases and 200 normal menopause...
متن کاملThe British Menopause Society and Women's Health Concern recommendations on the management of women with premature ovarian insufficiency.
This guidance document by the British Menopause Society provides recommendations on the assessment and management of women with premature ovarian insufficiency (POI). The consequences of POI are related to the decline in ovarian function and estrogen deficiency associated with the condition. These can be short-term menopausal symptoms and long-term effects on bone and cardiovascular health, cog...
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ژورنال
عنوان ژورنال: Obstetrics, Gynecology and Reproduction
سال: 2020
ISSN: 2500-3194,2313-7347
DOI: 10.17749/2313-7347/ob.gyn.rep.2020.173